Influence of ischemia-reperfusion injury on liver cancer and related mechanism
10.3969/j.issn.1001-5256.2019.06.042
- VernacularTitle:缺血再灌注损伤对肝癌的影响及作用机制
- Author:
Jianhao ZHENG
1
;
Chaoliu DAI
Author Information
1. Department of Hepatobiliary and Splenic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
reperfusion injury;
liver cancer;
free radicals;
molecular chaperones;
cytokines;
review
- From:
Journal of Clinical Hepatology
2019;35(6):1369-1373
- CountryChina
- Language:Chinese
-
Abstract:
In the process of the surgical treatment of liver cancer, blood flow occlusion at the porta hepatis is an important method to reduce intraoperative bleeding, and ischemia-reperfusion injury (IRI) resulting from such occlusion has an important effect on tumor cell. IRI can not only lead to tumor recurrence and metastasis, but also exert an inhibitory effect on tumor. Such influence is associated with various factors including free radicals, nitric oxide, inflammatory cytokines, and enzymes. An understanding of such effect and related mechanisms is of great importance to the research on the association between IRI and liver cancer and the selection of treatment methods for liver cancer.
