The biological characteristics of GP73 and its value in the diagnosis of liver fibrosis and cirrhosis
10.3969/j.issn.1001-5256.2019.06.040
- VernacularTitle:高尔基体蛋白73的生物学特征及在肝纤维化和肝硬化中的诊断价值
- Author:
Jiana LI
1
;
Ruiqi ZHENG
;
Na LI
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
Golgi protein 73;
diagnosis;
review
- From:
Journal of Clinical Hepatology
2019;35(6):1361-1364
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a necessary stage in the development of chronic liver diseases to liver cirrhosis. Liver cirrhosis is the end-stage change of various chronic liver diseases, and early diagnosis of liver fibrosis has an important value in timely treatment and prognosis. At present, liver biopsy, ultrasound, computed tomography, and magnetic resonance imaging are the main diagnostic methods for liver fibrosis and cirrhosis. Liver biopsy is the gold standard for the diagnosis of liver fibrosis and cirrhosis, but its clinical application is limited by invasiveness and sample error. Conventional noninvasive methods cannot meet the requirements for the diagnosis of liver fibrosis and cirrhosis. Therefore, searching for new serological markers for liver fibrosis and cirrhosis has become a research hotspot. Related studies have shown that serum Golgi protein 73 (GP73) can be used as a serum marker for the diagnosis of liver fibrosis and cirrhosis and has high clinical value. This article reviews the commonly used methods for the diagnosis of liver fibrosis and cirrhosis and elaborates on the biological characteristics of GP73 and its value in the diagnosis of liver fibrosis and cirrhosis.
