Value of fumarate hydratase antibody in differential diagnosis of autoimmune hepatitis and drug-induced liver injury
10.3969/j.issn.1001-5256.2019.06.029
- VernacularTitle:抗延胡索酸水合酶抗体对自身免疫性肝炎和药物性肝损伤的鉴别诊断价值
- Author:
Ying HAN
1
;
Jie CHEN
;
Jing SHAN
Author Information
1. Department of Hepatology and Immunology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
fumigate hydratase;
autoantibodies;
hepatitis, autoimmune;
drug-induced liver injury;
diagnosis, differential
- From:
Journal of Clinical Hepatology
2019;35(6):1326-1329
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the value of fumarate hydratase antibody (anti-FH) in the differential diagnosis of autoimmune hepatitis (AIH) and drug-induced liver injury (DILI). MethodsFrom March 2014 to December 2016, 105 patients with AIH who were hospitalized in Beijing You’an Hospital were enrolled as AIH group, and 92 patients with DILI were enrolled as DILI group. A total of 128 healthy individuals were enrolled as control group. ELISA was used to measure the serum level of anti-FH. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups. A consistency analysis of diagnostic compliance of anti-FH based on the Kappa test. The sensitivity, specificity, positive predictive value, and negative predictive value of anti-FH in the diagnosis of AIH were analyzed. ResultsCompared with the DILI group, the AIH group had significantly higher positive rate of anti-nuclear antibody (72.4% vs 55.4%, χ2 = 6147, P=0.013) and level of IgG ((18.3±6.1) g/L vs (15.2±5.4) g/L, t=-2566, P=0.011)). The AIH group had a significantly higher positive rate of anti-FH than the DILI group and the control group (36.2% (38/67) vs 6.5% (6/92) and 2.3% (3/128), χ2=59.959, P＜0.001). In the diagnosis of AIH, anti-FH had a sensitivity of 36.2%, a specificity of 93.5%, a positive predictive value of 86.4%, and a negative predictive value of 93.5%. ConclusionSerum anti-FH has a certain reference value in the differential diagnosis of AIH and DILI.
