In vitro cell model and mouse model of HBV cccDNA
10.3969/j.issn.1001-5256.2019.06.007
- VernacularTitle:HBV cccDNA的体外细胞模型和实验小鼠模型
- Author:
Yu SU
1
;
Yuanfei ZHU
;
Qingyou TIAN
Author Information
1. Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
cccDNA;
cell culture model;
models, animal
- From:
Journal of Clinical Hepatology
2019;35(6):1205-1211
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B virus (HBV) infection remains a major public health threat worldwide. Current antiviral drugs can effectively inhibit the replication of HBV, but they fail to achieve a complete cure. As the original template for HBV replication, covalently closed circular DNA (cccDNA) is intrinsically stable in vivo and is regarded as the molecular basis for persistent HBV infection and the key target for the cure of HBV infection. Studies on biosynthesis, metabolism, and regulation of HBV cccDNA have been limited by the low copy number of cccDNA within cells and the lack of sensitive and reliable detection methods. Establishment of appropriate research models of cccDNA helps to understand related biological processes. This article reviews the latest research advances in cell models and mouse models of HBV cccDNA, in order to facilitate future studies on HBV virology and development of antiviral drugs against HBV.
