Mechanism of action of microRNA in the regulation of hepatic ischemia-reperfusion injury
10.3969/j.issn.1001-5256.2019.07.045
- VernacularTitle:microRNA调控肝缺血再灌注损伤的作用机制
- Author:
Shilong ZHANG
1
;
Cijun PENG
;
Zanji FENG
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China
- Publication Type:Research Article
- Keywords:
reperfusion injury;
microRNAs;
apoptosis;
autophagy;
inflammation;
review
- From:
Journal of Clinical Hepatology
2019;35(7):1629-1631
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury is one of the most important factors affecting the prognosis of clinical hepatic surgery. Studies have shown that microRNAs can participate in the process of hepatic ischemia-reperfusion injury through multiple pathways. This article reviews the biosynthesis and function of microRNAs and the mechanisms of action of microRNAs in the regulation of hepatic ischemia-reperfusion injury through energy metabolism, apoptosis, autophagy, oxidative stress, and cellular inflammation. It is pointed out that the treatment targeting microRNAs has a promising future in the treatment of hepatic ischemia-reperfusion injury, and further studies are needed in the future.
