Role of long non-coding RNA in the development and progression of cholangiocarcinoma
10.3969/j.issn.1001-5256.2019.08.054
- VernacularTitle:长链非编码RNA在胆管癌发生发展中的作用
- Author:
Shilong ZHANG
1
;
Weidong GAO
;
Zanji FENG
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China
- Publication Type:Research Article
- Keywords:
bile duct neoplasms;
RNA, long noncoding;
pathologic processes
- From:
Journal of Clinical Hepatology
2019;35(8):1885-1888
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma is a malignant tumor originating from the epithelial cells of the bile duct, and its incidence and mortality rates keep increasing year by year. Unknown pathogenesis of this disease has led to the difficulties in early diagnosis and treatment. With the development of genetic engineering and bioinformatics, more and more studies have found that long non-coding RNA (lncRNA) is closely associated with the pathophysiological process of cholangiocarcinoma. This article summarizes the research advances in the role of lncRNA in mediating the biological behaviors of cell proliferation, apoptosis, metastasis, invasion, epithelial-mesenchymal transition, and drug resistance in cholangiocarcinoma, as well as the association of lncRNA with clinical features and prognosis.
