Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

VernacularTitle:Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点
Author: Weizhao WANG ¹ ; Xiaoxing XIANG
Author Information

1. Department of Gastroenterology, Dalian Medical University, Dalian, Liaoning 116044, China
Publication Type:Research Article
Keywords: hepatitis, autoimmune; T-lymphocytes, regulatory; T-lymphocytes, helper-inducers
From: Journal of Clinical Hepatology 2019;35(8):1874-1877
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis (AIH) is a chronic autoimmune disease in the liver, with major clinical manifestations of positive autoantibody, abnormal elevation of aminotransferases, and hypergammaglobulinemia. Current studies have shown that regulatory T (Treg)/T helper 17 (Th17) and T helper 1 (Th1)/T helper 2 (Th2) imbalance is one of the mechanisms of the development and progression of AIH. OX40 (also known as CD134, TNFRSF4, or ACT35) and its ligand OX40L are members of the tumor necrosis factor family, and they participate in immune response as co-stimulators of T cell activation and can regulate Treg/Th17 and Th1/Th2 balance, thus affecting the progression of various autoimmune diseases. However, there are few reports on the role of OX40 and OX40L in AIH. With reference to related articles, this article reviews the role of Treg/Th17 and Th1/Th2 balance in AIH and the potential association between OX40/OX40L (new targets for immunological diagnosis and treatment) and AIH.