Association of biological characteristics of hepatitis B virus with the progression of liver fibrosis
10.3969/j.issn.1001-5256.2019.08.041
- VernacularTitle:HBV生物学特性与肝纤维化进展的关系
- Author:
Xiujuan CHANG
1
;
Yinyin LI
;
Bin YANG
Author Information
1. Chinese PLA Medical School, Beijing 100853, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
liver cirrhosis;
genes;
genotype
- From:
Journal of Clinical Hepatology
2019;35(8):1834-1837
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) causes liver injury by stimulating host immune response and may lead to liver fibrosis, liver cirrhosis, and liver cancer. Progression of liver fibrosis is a key factor in liver disease-related death. This article summarizes the association of HBV genotype, HBV gene mutation in basic core promoter region/pre-C region, pre-S region, and X region, HBV gene splicing, HBV RNA, HBcAg, and HBsAg with the progression of liver fibrosis. It is pointed out that the above biological characteristics of HBV are closely associated with the progression of liver fibrosis.
