Interrelation between autophagy and oxidative stress in pathogenesis of nonalcoholic fatty liver
10.3969/j.issn.1001-5256.2018.08.048
- VernacularTitle:自噬与氧化应激在非酒精性脂肪性肝病发病机制中的关系
- Author:
Fan ZHOU
1
;
Junwei PENG
;
Fugang FAN
Author Information
1. Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver;
autophagy;
oxidative stress;
review
- From:
Journal of Clinical Hepatology
2018;34(8):1805-1808
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the result of the interaction between many factors, and “second hit” focusing on oxidative stress is a key factor for the progression of NAFLD. Autophagy has been a research hotspot in recent years, and more and more studies have shown that autophagy plays an important role in lipid metabolism in hepatocytes, inflammatory response, and liver fibrosis and is closely associated with oxidative stress. With reference to the latest research findings in China and foreign countries, this article analyzes the interrelation between autophagy and oxidative stress in the pathogenesis of NAFLD from the aspects of the association between autophagy and NAFLD and the association between oxidative stress and NAFLD. It is pointed out that the molecular mechanism of the regulation of oxidative stress by autophagy in the pathogenesis of NAFLD may be a research hotspot in future, and blockade or activation of a key pathway involved in the regulation of oxidative stress by autophagy may provide a new method for the treatment of NAFLD.
