Research advances in portal hypertension in patients with nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2018.08.047
- VernacularTitle:非酒精性脂肪性肝病并发门静脉高压的研究进展
- Author:
Min LI
1
;
Xiaorong MAO
Author Information
1. Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730030, China)
- Publication Type:Research Article
- Keywords:
nonalcoholic fatty liver disease;
portal hypertension;
endothelial dysfunction;
intrahepatic vascular resistance;
review
- From:
Journal of Clinical Hepatology
2018;34(8):1801-1804
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is often complicated by clinically significant portal hypertension (PHT) during its progression to liver cirrhosis, which is primarily caused by increased intrahepatic vascular resistance. The pathogenesis of PHT in NAFLD remains unclear. This article summarizes the current research status of PHT in NAFLD and related cellular and molecular mechanisms in the development of PHT, in order to provide a theoretical basis for novel preventive and therapeutic strategies for NAFLD.
