Interaction between the stimulator of interferon genes signaling pathway and HBV

VernacularTitle:干扰素基因刺激蛋白信号通路与HBV感染的相互作用
Author: Zhiqiang XU ¹ ; Qing WANG ; Xiucheng PAN
Author Information

1. Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China
Publication Type:Research Article
Keywords: hepatitis B virus; adaptor proteins, signal transducing; immunity, natural; review
From: Journal of Clinical Hepatology 2018;34(8):1779-1782
CountryChina
Language:Chinese
Abstract: Stimulator of interferon genes (STING) is a newly discovered adaptor protein in the innate immune system and plays an important role in innate immune response mediated by cytoplasmic DNA. Double-stranded DNA recognition receptors in cells are mediated by STING protein to produce type I interferon and other cytokines. Inadequate innate immune response and anti-hepatitis B virus (HBV) specific immune response are important causes of chronic HBV infection. This article introduces the discovery of STING and the latest research advances in its structure, briefly elaborates on the mechanism of activation of the STING signaling pathway, summarizes the research advances in the interaction between the STING signaling pathway and HBV, and points out the potential value of STING in clinical treatment.