Role of signal transduction and transcription factors STAT1 and STAT3 in the pathogenesis of hepatocellular carcinoma and liver failure
10.3969/j.issn.1001-5256.2018.09.040
- VernacularTitle:STAT1与STAT3在肝细胞癌及肝衰竭发病机制中的作用
- Author:
Mengdan GAO
1
;
Yonghong ZHANG
;
Yan ZHAO
Author Information
1. Clinical Laboratory Center, Beijing You′An Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
carcinoma， hepatocellular;
liver failure;
STAT1 transcription factor;
STAT3 transcription factor;
review
- From:
Journal of Clinical Hepatology
2018;34(9):2017-2020
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) and liver failure are common liver diseases in China and have extremely high incidence and mortality rates. Although there are many related studies, the detailed pathogenesis of these two diseases is still unknown. This article reviews the role of STAT1 and STAT3 phosphorylation proteins in the pathogenesis of HCC and liver failure, such as antiviral defense, acute phase response, liver injury, repair, inflammation, and transformation. A deep understanding of their role in the pathogenesis of HCC and liver failure and the development of related drugs with them as molecular targets play an important role in reducing mortality rate in clinical practice.
