Research advances in the structure and function of osteopontin and its effect in diagnosis and treatment of hepatocellular carcinoma

VernacularTitle:骨桥蛋白在肝细胞癌诊治中的作用
Author: Han WU ¹ ; Zhenli LI ; Hao XING
Author Information

1. Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China
Publication Type:Research Article
Keywords: carcinoma, hepatocellular; osteopontin; review
From: Journal of Clinical Hepatology 2018;34(9):1999-2003
CountryChina
Language:Chinese
Abstract: Osteopontin (OPN) is a widely distributed secretory protein and is involved in integrin-mediated cell signal transduction. It also plays an important role in the development, progression, and metastasis of hepatocellular carcinoma (HCC). OPN plays a pivotal role in biomineralization and innate immunity, participates in tumor growth and angiogenesis by interacting with integrin, and induces the recurrence and metastasis of HCC via multiple signal transduction. Combined measurement of OPN and other tumor biomarkers can improve the sensitivity of early diagnosis of HCC. OPN inhibitors may serve as a new target for the treatment of HCC and can improve the sensitivity of chemotherapeutic drugs. This article summarizes the recent studies on OPN and introduces the biological function of OPN and its role in the progression and diagnosis and treatment of HCC.