Association between HBV A1762T/G1764A double nucleotide substitution and liver diseases

VernacularTitle:HBV A1762T/G1764A双核苷酸替换与肝脏疾病的关系
Author: Xin LAI ¹ ; Taicheng ZHOU ; Jia WEI
Author Information

1. Department of Liver Disease, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China
Publication Type:Research Article
Keywords: hepatitis B virus; variation (genetics); review
From: Journal of Clinical Hepatology 2018;34(9):1990-1994
CountryChina
Language:Chinese
Abstract: HBV A1762T/G1764A double nucleotide substitution (also called TA mutation) is relatively common in liver diseases. Hepatocyte nuclear factor 4 (HNF4) is one of liver-enriched transcription factors, and TA mutation is located in the binding region of HNF4 and HBV and plays an important regulatory role in HBV gene transcription and replication. Several studies have pointed out that TA mutation may aggravate liver diseases after HBV infection and increase the risk of chronic liver failure and liver cancer; however, it is still unclear how TA mutation can aggravate liver disease after HBV infection, and more studies are needed for clarification in the future. This article reviews the association between HBV A1762T/G1764A double nucleotide substitution and liver diseases.