Thromboprophylaxis and bleeding control in patients with liver disease in the intensive care unit
10.3969/j.issn.1001-5256.2018.10.039
- VernacularTitle:重症监护病房肝病患者的血栓预防与出血控制
- Author:
Wenli XING
1
;
Qian LI
Author Information
1. Intensive Care Unit, Tianjin Second People′s Hospital & Tianjin Institute of Hepatology, Tianjin 300192, China
- Publication Type:Research Article
- Keywords:
liver diseases;
hemostatic disorders;
blood transfusion;
thrombosis;
review
- From:
Journal of Clinical Hepatology
2018;34(10):2237-2240
- CountryChina
- Language:Chinese
-
Abstract:
Liver diseases are associated with complex abnormalities in the coagulation system as the liver is involved in the synthesis of various coagulation-related proteins. Laboratory and clinical evidence suggests that patients with liver disease may achieve a state of rebalanced hemostasis, but such balance is relatively unstable, and thus bleeding and thrombosis events are observed in clinical practice. Patients with acute or chronic liver diseases might be admitted to the intensive care unit (ICU) due to serious complications such as bleeding and thrombosis. Gastrointestinal bleeding, systemic or local thrombosis, and coagulation events in extracorporeal circulation are common complications observed in patients with liver disease in the ICU. An individualized management plan of thromboprophylaxis and a wait-and-see policy for limited blood transfusion are reasonable for patients with liver disease.
