Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis
10.3969/j.issn.1001-5256.2018.10.037
- VernacularTitle:非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素
- Author:
Yanzhen CHEN
1
;
Chengliang CHEN
;
Yu HONG
Author Information
1. Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun 130033, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver;
liver cirrhosis;
review
- From:
Journal of Clinical Hepatology
2018;34(10):2227-2231
- CountryChina
- Language:Chinese
-
Abstract:
At present, non-alcoholic fatty liver disease (NAFLD) has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice, NAFLD is commonly seen in obese patients; however, it is not rare among non-obese individuals, especially in the Asian population. Non-obese NAFLD patients have similar metabolic profiles to obese NAFLD patients, but many studies have revealed that compared with obese NAFLD, non-obese liver fibrosis and liver cirrhosis have unique features. This article reviews the research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis in recent years, in order to gain a better understanding of the prevention, diagnosis, and treatment of this disease.
