Research advances in anticoagulant therapy for liver fibrosis
10.3969/j.issn.1001-5256.2018.10.036
- VernacularTitle:抗凝治疗抑制肝纤维化进程的研究进展
- Author:
Yifu XIA
1
;
Chunqing ZHANG
Author Information
1. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
thrombosis;
anticoagulants;
review
- From:
Journal of Clinical Hepatology
2018;34(10):2224-2226
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a pathological process in which chronic liver disease develops into liver cirrhosis. It is caused by diffuse proliferation of liver fibrous tissue on the basis of extensive necrosis of liver cells, resulting in destruction of the normal structure and blood supply of liver lobules. In the process of liver fibrosis, platelets aggregate in the sinusoids to form microthrombi, which may promote liver fibrosis. This article briefly describes the relationship between platelets and liver fibrosis and reviews the latest advances in anticoagulant therapy for improving liver function and liver fibrosis score. The molecular mechanism of anticoagulant therapy remains to be studied, and safe and effective anticoagulants may provide a new approach for the treatment of liver fibrosis.
