Significance of hepatitis B virus pregenomic RNA in the progression of chronic hepatitis B
10.3969/j.issn.1001-5256.2018.10.035
- VernacularTitle:HBV pgRNA在慢性乙型肝炎进程中的可能意义
- Author:
Ning TAN
1
;
Hao LUO
;
Xiaoyuan XU
Author Information
1. Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
- Publication Type:Research Article
- Keywords:
hepatitis B, chronic;
HBV pregenomic RNA;
hepatitis B core-related antigen;
review
- From:
Journal of Clinical Hepatology
2018;34(10):2221-2223
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is the direct transcription product of HBV covalently closed circular DNA (cccDNA) and can reflect the transcriptional activity of HBV cccDNA and the progression of chronic hepatitis B, which provides guidance for clinical treatment and prognostic prediction. Compared with other common serological markers for HBV infection, HBV pgRNA is more sensitive in reflecting HBV replication and the effect of antiviral therapy has a certain predictive value for endpoints in the stages of antiviral therapy. This article elaborates on the significance of HBV pgRNA in reflecting the changes in disease conditions with reference to the correlation of HBV pgRNA with HBcrAg and HBV cccDNA.
