Clinical features of autoimmune hepatitis in children: An analysis of 10 cases
10.3969/j.issn.1001-5256.2018.10.020
- VernacularTitle:儿童自身免疫性肝炎10例临床特征分析
- Author:
Jie CHEN
1
;
Yanmin LIU
;
Chunyang HUANG
Author Information
1. Department of Hepatology and Immunology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
hepatitis, autoimmune;
disease attributes;
child
- From:
Journal of Clinical Hepatology
2018;34(10):2164-2168
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical features and treatment outcome of children with autoimmune hepatitis (AIH). MethodsA retrospective analysis was performed for the clinical data, liver pathology, treatment outcome, and follow-up data of 10 children with AIH who were treated in Beijing YouAn Hospital, Capital Medical University, from December 2008 to December 2017. ResultsThe children were aged 3-16 years (median 10 years), and girls accounted for 70%. Of all patients, 5 had type 1 AIH, and 5 had type 2 AIH; 3 (30%) had an acute onset, 2 (20%) had a subacute onset, and 5 (50%) had a chronic onset. Elevation of aminotransferases was found in 8 children (80%), and elevations of bilirubin, gamma-glutamyl transpeptidase, and immunoglobulin G were found in 7 children (70%), 7 children (70%), and 6 children (60%), respectively. Among the 7 children who underwent liver biopsy, 3 had grade ≥3 liver inflammation, 4 had stage ≥3 liver fibrosis, 5 had interface hepatitis, 5 had plasma cell infiltration, 4 had rosette-like annulation of hepatocytes, and 7 had lymphocyte infiltration. One child died, and one was lost to follow-up; among the other 8 children, 6 had good response, 1 experienced recurrence, and one had poor response. 4 patients with type 2 AIH were treated with glucocorticoids combined with azathioprine, the disease was effectively controlled. ConclusionChildren with AIH have diverse clinical manifestations, and some children have serious conditions. Most patients with type 2 AIH need the treatment of glucocorticoids combined with azathioprine.
