Diagnosis, treatment, and prevention of postcholecystectomy syndrome
10.3969/j.issn.1001-5256.2018.11.043
- VernacularTitle:胆囊切除术后综合征的诊治和预防
- Author:
Huanhuan LIU
1
;
Yu TIAN
;
Yang PENG
Author Information
1. Second Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China
- Publication Type:Research Article
- Keywords:
postcholecystectomy syndrome;
cholecystectomy, laparoscopic;
diagnosis;
therapeutics;
universal precautions;
review
- From:
Journal of Clinical Hepatology
2018;34(11):2464-2468
- CountryChina
- Language:Chinese
-
Abstract:
Postcholecystectomy syndrome (PCS) is a common syndrome with complex etiologies after laparoscopic cholecystectomy, rather than a specific disease. In addition to bile duct stones, bile duct injury, and sphincter of Oddi dysfunction, PCS is also associated with the abnormalities in bile acid pool, farnesoid X receptor, and GPBAR1/TGR5 pathways after surgery, reductions in fibroblast growth factor 19 and surfactant protein D, changes in gastrointestinal hormones such as motilin and cholecystokinin, and disappearance of various physiological reflexes and nerve reflexes involving the gallbladder. All these changes in physiological function can induce PCS. As the number of patients undergoing laparoscopic cholecystectomy is increasing year by year, the incidence rate of PCS is also increasing. This article briefly summarizes the etiology, pathophysiology, diagnosis, treatment, and prevention of PCS.
