Research advances in the biomarkers for the early diagnosis of hepatorenal syndrome
10.3969/j.issn.1001-5256.2018.11.040
- VernacularTitle:肝肾综合征早期生物学标志物的研究进展
- Author:
Lanlan CHEN
1
;
Wen HAN
;
Jingjing LIU
Author Information
1. Department of Gastroenterology, Affiliated Hospital of YanAn University, YanAn, Shaanxi 716000,China
- Publication Type:Research Article
- Keywords:
hepatorenal syndrome;
biological markers;
review
- From:
Journal of Clinical Hepatology
2018;34(11):2448-2452
- CountryChina
- Language:Chinese
-
Abstract:
Hepatorenal syndrome (HRS) is one of the most serious complications of end-stage liver disease. Type Ⅰ/Ⅱ HRS has a high short-term mortality rate and poor prognosis. The diagnostic criteria for HRS based on serum creatinine cannot keep up with the world, and early diagnosis is of great importance to the treatment and prognosis of HRS. This article introduces the value and clinical significance of seven biomarkers for renal injury in the early diagnosis, differential diagnosis, and prognostic evaluation of HRS. It is pointed out that neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1 may be the biomarkers for early identification of renal injury in patients with liver cirrhosis. A combination of multiple biological indicators, imaging examination, and interventional techniques might be a feasible method for early diagnosis of HRS in future.
