Biological functions of apoptosis stimulating protein of p53 2 and its role in liver diseases
10.3969/j.issn.1001-5256.2018.11.039
- VernacularTitle:p53凋亡刺激蛋白2的生物学功能及在肝病中的作用
- Author:
Yizhi ZHANG
1
;
Hongbo SHI
;
Yu CHEN
Author Information
1. Artificial Liver Treatment & Training Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
liver diseases;
tumor suppressor protein p53;
review
- From:
Journal of Clinical Hepatology
2018;34(11):2443-2447
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis stimulating protein of p53 2 (ASPP2) is a member of the apoptosis stimulating proteins of p53 and can specifically bind to the core region of p53 protein and enhance the ability of p53 to promote transcription of apoptotic genes. At present, it is believed that ASPP2 plays an important role in regulating cell apoptosis, autophagy, proliferation and affecting the progression of inflammation and tumors. This article summarizes the main biological functions of ASPP2 and the research advances in the role of ASPP2 in hepatocellular carcinoma, hepatitis C, and nonalcoholic fatty liver disease. Studies have shown that ASPP2 can regulate cell apoptosis and may be a potential therapeutic target for a variety of diseases.
