Research advances in gut microbiota in liver cirrhosis and related complications
10.3969/j.issn.1001-5256.2018.11.037
- VernacularTitle:肠道微生物在肝硬化及相关并发症中的研究进展
- Author:
Bingjie LU
1
;
Yahong ZHAO
;
Yongtong AN
Author Information
1. Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
enterobacteriaceae;
liver cirrhosis;
complication;
review
- From:
Journal of Clinical Hepatology
2018;34(11):2433-2437
- CountryChina
- Language:Chinese
-
Abstract:
Liver cirrhosis is an end-stage fibrotic disease of chronic liver injury induced by various factors. Many studies have shown that gut microbiota (GM) are involved in the development and progression of liver cirrhosis and related complications, such as portal hypertension, hepatic encephalopathy, spontaneous bacterial peritonitis, and hepatocellular carcinoma. In addition, impaired intestinal barrier, compromised liver immunity, and bacterial translocation play a critical role in the progression of liver cirrhosis. This article summarizes the role of GM in liver cirrhosis and related complications and research advances and problems in GM as a therapeutic target, in order to provide new thoughts for clinical diagnosis and treatment.
