Role of the Wnt signaling pathway in the development and progression of liver fibrosis
10.3969/j.issn.1001-5256.2018.11.033
- VernacularTitle:Wnt信号通路与肝纤维化发生发展的关系
- Author:
Dongkang ZHAO
1
;
Weiwei LUO
;
Shuiping YU
Author Information
1. Guilin Medical University, Guilin, Guangxi 541000, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
adipocytes;
signal transduction;
review
- From:
Journal of Clinical Hepatology
2018;34(11):2415-2419
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis has a complex pathogenesis and involves various intracellular and extracellular signal transduction pathways, but its specific pathogenesis remains unclear. Recent studies have confirmed that the activation of hepatic stellate cells due to abnormal activation of the Wnt signaling pathway is an important cause of liver fibrosis, and targeted inhibition of the Wnt signaling pathway can prevent the activation and proliferation of hepatic stellate cells and thus achieve an antifibrogenic effect. This article reviews the role of the Wnt signaling pathway in the development and progression of liver fibrosis and the latest research advances in the antifibrogenic effect of the interference of the Wnt signaling pathway, in order to provide new ideas for anti-hepatic fibrosis and the delay of early-stage cirrhosis.
