Clinical and pathological features of cholestatic liver injury
10.3969/j.issn.1001-5256.2018.11.004
- VernacularTitle:淤胆型肝损伤的临床与病理
- Author:
Duxian LIU
1
;
Lanxia LIU
;
Yongfeng YANG
Author Information
1. Department of Pathology, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine & The Second Hospital of Nanjing, Nanjing 210003, China
- Publication Type:Research Article
- Keywords:
liver diseases;
cholestasis;
disease attributes;
pathology
- From:
Journal of Clinical Hepatology
2018;34(11):2283-2288
- CountryChina
- Language:Chinese
-
Abstract:
Major causes of cholestasis include abnormal bile metabolism, obstructed bile flow and regurgitation, and bile duct injury and obstruction. Abnormal bile metabolism is mainly caused by gene abnormality, while obstructed bile flow is often caused by bile duct injury or occlusion due to cholangitis. Abnormal bile metabolism is the most common cause of progressive familial intrahepatic cholestasis (PFIC), while autoimmune cholangitis is the major cause of bile duct injury. Both congenital/autoimmune bile duct injury and secondary/acquired ductular reaction had relatively specific histopathological changes, and a confirmed diagnosis needs a comprehensive analysis based on clinical, pathological, imaging, immunological, and genetic examinations. This article elaborates on the research advances in the pathomorphology of autoimmune bile duct injury and PFIC and introduces the similar lesions, in order to provide a reference for the clinical diagnosis of bile duct injury and cholestatic liver diseases.
