Clinical features, pathogenesis, and diagnosis and treatment of different types of hepatic sinusoidal obstruction syndrome
10.3969/j.issn.1001-5256.2019.01.046
- VernacularTitle:不同类型肝窦阻塞综合征的临床特征、发病机制与诊治
- Author:
Zhenli LIU
1
;
Zuopeng FAN
;
Yusong GOU
Author Information
1. Department of Hepatitis C & Toxic Liver Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
hepatic veno-occlusive disease;
alkaloids;
hematopoietic stem cell transplantation;
review
- From:
Journal of Clinical Hepatology
2019;35(1):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic sinusoidal obstruction syndrome (HSOS) is a sinusoidal or small venous fibrous occlusive disease characterized by small hepatic vessel damage, especially sinusoidal endothelial cell injury. Exposure to certain exogenous toxins is the main cause of the disease. Based on etiology, HSOS is mainly classified into pyrrolidine alkaloid-related HSOS, hematopoietic stem cell transplantation-related HSOS, and HSOS of unknown etiology. This article summarizes the types of HSOS and reviews the research advances in clinical manifestations, pathogenesis, diagnosis, and treatment of HSOS.
