Research advances in direct-acting antiviral agents in the treatment of hepatitis C virus-related liver cirrhosis
10.3969/j.issn.1001-5256.2019.01.041
- VernacularTitle:直接抗病毒药物治疗HCV相关肝硬化的效果及安全性
- Author:
Guoqiong YOU
1
;
Li WANG
;
Meng DUAN
Author Information
1. Second Department of Hepatology, Chengdu Public Health Medical Center, Chengdu 610000, China
- Publication Type:Research Article
- Keywords:
hepacivirus;
liver cirrhosis;
antiviral agents;
therapeutics;
review
- From:
Journal of Clinical Hepatology
2019;35(1):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Liver cirrhosis is common in clinical practice and is the common clinical outcome of various chronic liver diseases including chronic hepatitis C virus (HCV) infection. Before the development of direct-acting antiviral agents (DAAs), anti-HCV therapy based on pegylated interferon (PEG-IFN.) and ribavirin (RBV) has a poor clinical effect due to the presence of liver cirrhosis, and decompensated liver cirrhosis itself is an absolute contraindication for PEG-IFN treatment. DAAs have gradually become the first-line drug for HCV infection, and many studies have shown that DAAs have good clinical effects and tolerability in the treatment of cirrhotic patients with HCV infection. On the one hand, DAAs have better clinical effect and safety than PEG-IFN/RBV in patients with compensated liver cirrhosis; on the other hand, patients with decompensated liver cirrhosis are tolerant to DAAs, and although they have a lower proportion of patients with sustained virologic response than normal patients, they can still benefit from DAAs from many aspects. This article reviews the latest research advances in DAAs in patients with HCV-related liver cirrhosis, in order to provide a reference for clinical diagnosis and treatment.
