Effect of various cells on the activation of hepatic stellate cells in liver microenvironment
10.3969/j.issn.1001-5256.2019.02.042
- VernacularTitle:肝脏微环境中各种细胞对肝星状细胞活化的影响
- Author:
Ying XU
1
;
Dingqi ZHANG
;
Jiamei CHEN
Author Information
1. Key Laboratory of Liver and Kidney Diseases (Ministry of Education) & Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
adipocytes;
cytokines;
review
- From:
Journal of Clinical Hepatology
2019;35(2):424-430
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a dynamic pathological process characterized by excessive deposition of extracellular matrix (ECM) or hyperplasia of scar tissue. The activation of hepatic stellate cells (HSCs) is generally considered the central link in the formation of liver fibrosis. HSC activation is regulated by various factors in liver microenvironment, including physical and chemical stimulations and intercellular interactions. Intrinsic cells and immune cells in the liver and HSCs together establish a complex regulatory system to regulate HSC activation and regression. This article introduces the regulatory effect of the cells in liver microenvironment on HSC activation, in order to expand thinking for the research on new diagnosis and treatment methods for liver fibrosis.
