Mechanism and current status of simvastatin in treatment of cirrhotic portal hypertension
10.3969/j.issn.1001-5256.2019.02.037
- VernacularTitle:辛伐他汀治疗肝硬化门静脉高压症的作用机制及应用现状
- Author:
Huan WU
1
;
Long WU
;
Jing YANG
Author Information
1. Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
portal hypertension;
simvastatin;
therapeutics;
review
- From:
Journal of Clinical Hepatology
2019;35(2):402-405
- CountryChina
- Language:Chinese
-
Abstract:
Besides related etiologies, portal hypertension (PHT) is considered an important physiological link in promoting liver dysfunction. Literature review has shown that compared with the conventional drugs for the prevention and treatment of PHT, simvastatin can induce the expression of Kruppel-like factor-2 and nitric oxide to improve liver function and reduce cirrhotic portal venous pressure. Related analysis shows that simvastatin can be widely used in clinical practice to improve portal vein hemodynamics in cirrhotic patients.
