The role of enterohepatic circulation of bile acids and intestinal microbiota in the pathogenesis and treatment of cholestatic liver disease
10.3969/j.issn.1001-5256.2019.02.007
- VernacularTitle:胆汁酸的肝肠循环及肠道微生态在胆汁淤积性肝病发病和治疗中的作用
- Author:
Haoyu JIA
1
;
Changqing YANG
Author Information
1. Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai 200065, China
- Publication Type:Research Article
- Keywords:
cholestasis;
cholic acids;
enterohepatic circulation;
intestinal microbiota
- From:
Journal of Clinical Hepatology
2019;35(2):270-274
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver disease refers to a liver disorder caused by cholestasis, which arise from a series of etiologies such as viruses, bacteria, parasites, drugs, poisons, autoimmunity, alcohol, stones, tumors, genetics, and metabolism. This disease has the main manifestations of a change in bile flow and excessive accumulation of bile acid toxicity. In the pathogenesis of cholestatic liver disease, not only does the enterohepatic circulation of endogenous bile acids work, but also the intestinal microbiota plays an important role by regulating metabolism and causing immune responses. In addition, more attention has been paid to the close interaction between intestinal microbiota and the enterohepatic circulation of bile acids. Bile acids can alter the composition of intestinal microbiota, which in turn affects the bile acid pool. In recent years, there has been increasing research on the relationship of the enterohepatic circulation of bile acids and intestinal microbiota with cholestatic liver disease, which may provide new research directions for the pathogenesis and treatment of cholestatic liver disease.