Pathogenesis of cholestasis-induced liver fibrosis and thoughts for blockade
10.3969/j.issn.1001-5256.2019.02.002
- VernacularTitle:胆汁淤积导致肝纤维化的机制及其阻断策略
- Author:
Ruiling CHEN
1
;
Xiong MA
Author Information
1. Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine & Shanghai Institute of Digestive Diseases, Shanghai 200001, China
- Publication Type:Research Article
- Keywords:
cholestasis;
liver cirrhosis;
bile acids and salts
- From:
Journal of Clinical Hepatology
2019;35(2):247-251
- CountryChina
- Language:Chinese
-
Abstract:
Cholestasis refers to a pathological state of disorders in the formation, secretion, and excretion of bile flow, and liver fibrosis is a process of tissue repair induced by liver injury. Cholestatic liver disease is a chronic liver disease caused by cholestasis, progressive bile duct injury, and persistent intrahepatic inflammation, and it may cause cholangiocyte and hepatocyte injury, which will gradually progress to liver fibrosis. With reference to the current research advances, this article reviews the pathogenesis of cholestasis-induced liver fibrosis and the strategies for blockade.
