Current status and research interests of the diagnosis and treatment of cholestatic liver disease
10.3969/j.issn.1001-5256.2019.02.001
- VernacularTitle:胆汁淤积性肝病的诊治现状及研究方向
- Author:
Yuecheng YU
1
;
Chengwei CHEN
Author Information
1. Liver Disease Center of PLA, General Hospital of Eastern Theater Command/Bayi Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210002, China
- Publication Type:Research Article
- Keywords:
cholestasis;
liver cirrhosis;
enterohepatic circulation;
liver failure;
diagnosis;
therapeutics;
editorial
- From:
Journal of Clinical Hepatology
2019;35(2):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver disease (CSLD) is a group of liver diseases which can cause cholestasis and has a complex etiology. Its pathogenesis remains unclear, and there are still no effective treatment measures. In the recent decade, new achievements have been made on various aspects of CSLD, which provides more help to accurate diagnosis and treatment and reflects many pending issues which need further research. This article introduces the research advances and problems in CSLD from the following six aspects: the “ascending” pathophysiology of CSLD, mechanisms of cholestasis-induced liver fibrosis and related management measures, association of enterohepatic circulation and intestinal microbiota with CSLD, pathogenesis and diagnosis/treatment of drug-induced cholestasis, pathogenesis and management of liver failure-associated cholestasis, and research advances in treatment targets and drug research and development for CSLD.
