Function and mechanism of action of the PD-1/PD-L1 pathway in liver diseases
10.3969/j.issn.1001-5256.2019.03.050
- VernacularTitle:PD-1/PD-L1信号通路在肝脏疾病中的功能及作用机制
- Author:
Siyu PAN
1
;
Zhixin WANG
;
Ying ZHOU
Author Information
1. Department of Hepatopancreatobiliary Surgery, Qinghai University Affiliated Hospital, Xining 810000, China
- Publication Type:Research Article
- Keywords:
liver diseases;
intercellular signaling peptides and proteins;
programmed death 1;
review
- From:
Journal of Clinical Hepatology
2019;35(3):672-676
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death-1 (PD-1) is an important immunosuppressive molecule which interacts with its ligand programmed death-ligand 1 (PD-L1) and plays an important role in central/peripheral immune tolerance, transplantation immunity, tumor immune escape, and autoimmune disease. At present, there is still no systematic understanding of the role of the PD-1/PD-L1 pathway in the development and progression of liver diseases. This article summarizes related studies on the role of the PD-1/PD-L1 pathway in the progression of liver diseases and reviews the immunoregulatory function of the PD-1/PD-L1 pathway and its role in liver diseases. It is pointed out that the PD-1/PD-L1 pathway is involved in immunoregulatory function of the liver and plays an important role in the development and progression of liver inflammation, autoimmune liver diseases, viral liver diseases, tumor immune escape, transplantation rejection reaction, induced immune response, and autoimmune tolerance. Intervention of the PD-1/PD-L1 pathway may provide new strategies and directions for the prevention and treatment of liver disease.
