Spleen-strengthening and dampness-removing therapy exerts a therapeutic effect on nonalcoholic fatty liver disease by regulating hepatic MTP promoter methylation
10.3969/j.issn.1001-5256.2019.03.047
- VernacularTitle:健脾化湿法调控肝脏脂质输出基因甲基化治疗非酒精性脂肪性肝病的理论探讨
- Author:
Tao LIU
1
;
Qiuling XU
Author Information
1. Hainan Medical College, Haikou 571101, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
the principle of nourishing spleenand dispelling dampness;
DNA methylation;
lipoproteins, LDL;
review
- From:
Journal of Clinical Hepatology
2019;35(3):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is the most common risk factor for diabetes mellitus and cerebrovascular and cardiovascular diseases. The prevalence of NAFLD is increasing rapidly with the improvement in living. Microsome triglyceride transfer protein (MTP) is a key enzyme for outward transport of liver lipids, and the increase in MTP promoter methylation is an important factor for liver lipid deposition in NAFLD. Traditional Chinese medicine believes that “spleen Qi transfers essence”, and the lipid transport function of MTP may be one of the manifestations of “spleen Qi transfers essence”. Clinical studies have shown that the spleen-strengthening and dampness-removing principle is of great importance in the treatment of NAFLD. By reviewing related articles, this article points out that the spleen-strengthening and dampness-removing therapy can improve NAFLD by regulating MTP promoter methylation, increasing the level of hepatic MTP, promoting the outflow of liver lipids, and alleviating lipid deposition.
