Biological function and regulatory mechanism of epithelial-mesenchymal transition-related long non-coding RNAs in liver cancer
10.3969/j.issn.1001-5256.2019.03.046
- VernacularTitle:上皮-间质转化相关长链非编码RNA在肝癌中的生物学功能及调控机制
- Author:
Yuan WANG
1
;
Tao GUO
;
Jinghu LI
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
oncogenes;
lncRNA;
epithelial cells;
stromal cells;
cell transformation, neoplastic;
review
- From:
Journal of Clinical Hepatology
2019;35(3):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer has a high degree of malignancy, and many oncogenes and tumor suppressor genes play an important regulatory role in the development and progression of liver cancer. Epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells transform into mesenchymal cells, which can increase the migration and invasion abilities of tumor cells. Long non-coding RNAs (lncRNAs) can regulate EMT process in various ways. This article reviews the research advances in the main biological functions and regulatory mechanisms of EMT-related lncRNAs in liver cancer.
