Severe alcoholic hepatitis and acute-on-chronic liver failure
10.3969/j.issn.1001-5256.2019.03.008
- VernacularTitle:重症酒精性肝炎与慢加急性肝衰竭
- Author:
Furong，WANG SUN
1
Author Information
1. Department of Elderly Gastroenterology, the First Hospital of China Medical University, Shenyang 118001, China
- Publication Type:Research Article
- Keywords:
hepatitis, alcoholic;
acute-on-chronic liver failure;
pathologic processes;
risk assessmen;
therapeutics
- From:
Journal of Clinical Hepatology
2019;35(3):489-493
- CountryChina
- Language:Chinese
-
Abstract:
Rapid progression or aggravation of jaundice, coagulation abnormalities and liver-related complications in patients with alcoholic hepatitis indicates that they may develop severe alcoholic hepatitis. Some of these patients can progress acute-on-chronic liver failure with acute insults, such as infection and binge drinking and binge, showing as acute decompensation, organ failure and high 28-day mortality rate. Early identification and effective intervention can improve the prognosis of acute-on-chronic liver failure. Intestinal barrier dysfunction and liver-gut axis imbalance play an important role in the development of severe alcoholic hepatitis and acute-on-chronic liver failure. It is important to improve the basic nutritional status of patients. Effective drug therapies are limited in improving the condition and prognosis of acute-on-chronic liver failure. Early liver transplantation can bring great benefits to these patients.
