Application status and future prospect of the Gao-Binge model in alcoholic liver disease
10.3969/j.issn.1001-5256.2019.03.007
- VernacularTitle:Gao-Binge模型在酒精性肝病研究领域应用现状及未来前景
- Author:
Ke ZHOU
1
;
Hua WANG
Author Information
1. School of Pharmacy, Institute of Liver Diseases, Anhui Medical University, Hefei 230032, China
- Publication Type:Research Article
- Keywords:
liver diseases, alcoholic;
models, animal;
Gao-Binge model
- From:
Journal of Clinical Hepatology
2019;35(3):485-488
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of alcoholic liver disease remains unclear, mainly due to the lack of accurate animal models in experiments. Many different animal models have been established to mimic alcoholic liver disease in patients, which have both advantages and disadvantages. Among these models, the Gao-Binge model is widely used in the experiments because it highly mimics the drinking pattern in patients. It is more persuasive that the pathogenesis and therapeutic drugs have been examined in the Gao-Bingemodel. Although there are some limits in the Gao-Binge model, it is no doubt that this model has high value and future prospect in the study of alcoholic liver disease because of short duration time, low cost and good repeatability. Finally, the Gao-Binge model has also been used to study alcohol-induced damage to other organs such as the heart, pancreas, adipose tissue etc.
