Association between nuclear factor-erythroid 2-related factor-2 antioxidant pathway and liver diseases
10.3969/j.issn.1001-5256.2019.04.050
- VernacularTitle:核因子E2相关因子2抗氧化通路与肝脏疾病的关系
- Author:
Guona HE
1
;
Fengjun SHEN
Author Information
1. Department of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
liver diseases;
NF-E2-related factor 2;
oxidative stress;
review
- From:
Journal of Clinical Hepatology
2019;35(4):930-933
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-erythroid 2-related factor-2 (Nrf2) is an important transcription factor for cells to resist oxidative stress. It interacts with antioxidant response elements to induce the expression of downstream protective phase II detoxification enzymes and antioxidant enzymes and thus exerts a protective effect on cells. Oxidative stress is the common pathogenesis of many liver diseases, and the Nrf2-ARE antioxidant pathway is an important anti-oxidative stress pathway in vivo. It can induce the expression of downstream target genes and thus plays an important role in the development, progression, and prevention of liver diseases. This article briefly describes the mechanism of action of the Nrf2 antioxidant pathway in the development and progression of liver diseases and points out that Nrf2 may be a potential target for the prevention or treatment of liver diseases.
