Recent advances in drug-induced liver injury: Potential mechanisms, pathological features, and biomarkers
10.3969/j.issn.1001-5256.2019.04.049
- VernacularTitle:药物性肝损伤的潜在机制、病理特点及生物标志物
- Author:
Wenjing GENG
1
;
Hui LIU
;
Huiguo DING
Author Information
1. Department of Hepatology and Gastroenterology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
drug-induced liver injury;
pathologic processes;
biological markers;
review
- From:
Journal of Clinical Hepatology
2019;35(4):925-929
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury (DILI) is one of the main causes of acute liver failure, black box warnings, and drug withdrawal from the market, and it is also a major concern in public health, drug research and development, and the pharmaceutical industry. However, a lack of specific diagnostic markers for DILI makes the diagnosis of this disease a major challenge for clinicians. This article summarizes the recent advances in DILI research, including potential mechanisms, pathological features, biomarkers, and in vitro methods, in order to provide a reference for clinical and pathological diagnosis and prognostic evaluation of DILI.
