Influence of intestinal dysbacteriosis on liver cirrhosis
10.3969/j.issn.1001-5256.2019.04.040
- VernacularTitle:肠道菌群失调对肝硬化的影响
- Author:
Yunpeng LI
1
;
Xinhong WANG
;
Dekai ZHANG
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China
- Publication Type:Research Article
- Keywords:
liver cirrhosis;
enterobacteriaceae;
bacterial translocation;
review
- From:
Journal of Clinical Hepatology
2019;35(4):887-890
- CountryChina
- Language:Chinese
-
Abstract:
Liver cirrhosis is a progressive chronic liver disease due to one or more causes, with diffuse fibrosis in liver tissue, pseudolobules, and regenerative nodules as major histological features. Once liver cirrhosis enters the decompensated stage, the liver and several other organs are injured, which can hardly be recovered or reversed. This article introduces the process of Toll-like receptors in recognizing the changes in intestinal flora and the influence of this process on the development and progression of liver cirrhosis, as well as the protective effect of bile acid against liver cirrhosis by regulating intestinal flora. This article also reviews the advances in delaying liver cirrhosis after the treatment of intestinal dysbacteriosis and points out that the treatment of intestinal dysbacteriosis may become the major direction of liver cirrhosis treatment in future.
