The role of autophagy in the development and progression of acute pancreatitis
10.3969/j.issn.1001-5256.2019.05.051
- VernacularTitle:自噬在急性胰腺炎发生发展中的作用
- Author:
Chunyun LI
1
;
Ruixia LIU
;
Chenghong YIN
Author Information
1. Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
- Publication Type:Research Article
- Keywords:
pancreatitis;
autophagy;
tysosome-associated membrane glycoproteins;
inflammation;
review
- From:
Journal of Clinical Hepatology
2019;35(5):1157-1160
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is an exocrine inflammatory disease of the pancreas, the pathophysiological mechanism of AP remains unclear. Autophagy is an important pathway of metabolic degradation in cells, and autophagy impairment is closely associated with the development and progression of many diseases. Recent studies have found that the process of autophagy is abnormal in AP, with impaired fusion of autophagosome and lysosome and a significant reduction in the degradation function of autolysosome. Abnormal activation of pancreatic enzymes and inflammatory response is the key event in the initiation of AP, and abnormal autophagy is closely associated with these two events. The study of the upstream and downstream mechanisms of autophagy dysfunction in AP may help to find new molecular targets and strategies for the treatment of AP.
