Current status and perspectives of prognostic markers for liver failure
10.3969/j.issn.1001-5256.2019.05.046
- VernacularTitle:肝衰竭预后相关标志物的应用现状与展望
- Author:
Yeying LIU
1
;
Ting WANG
;
Aihu DOU
Author Information
1. Intractable Hepatic Diseases and Artificial Liver Treatment & Training Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
liver failure;
prognosis;
biological markers;
review
- From:
Journal of Clinical Hepatology
2019;35(5):1135-1139
- CountryChina
- Language:Chinese
-
Abstract:
Accurate judgment of conditions and prognosis has important clinical significance in improving survival rate and optimal distribution of liver source in patients with liver failure. This article reviews the current application of prognostic markers for liver failure such as alanine aminotransferase, aspartate aminotransferase, total bilirubin, prothrombin time, prothrombin time activity, and international normalized ratio and summarizes the new markers discovered in recent years, such as inflammatory response-related markers, neutrophil gelatinase-associated lipocalin, immune response-related markers, keratin, intestinal flora, microRNAs, liver failure autoantigen and autoantibody, and hemodynamic disorder. It is pointed out that the prognosis of liver failure is affected by many factors and there is still a lack of more sensitive and effective markers and a standardized prognostic scoring system. The new markers used alone or in combination with traditional markers may help to improve the sensitivity and specificity of prognostic evaluation of liver failure.
