Mechanism of action of protein phosphatase 2A in the promotion and inhibition of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2019.05.044
- VernacularTitle:蛋白磷酸酶2A在肝细胞癌中的促进与抑制作用机制
- Author:
Chenglei YANG
1
;
Shen HUANG
;
Zhiming ZHANG
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
protein phosphatase 2;
gene expression regulation;
review
- From:
Journal of Clinical Hepatology
2019;35(5):1123-1128
- CountryChina
- Language:Chinese
-
Abstract:
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase involved in many signaling pathways associated with cell growth and proliferation, and it also regulates many cellular processes. With an in-depth exploration of PP2A in the process of cell activity, especially malignant tumors, the association between PP2A and hepatocellular carcinoma (HCC) has attracted more and more attention in recent years; however, there is still a controversy over whether PP2A can promote or inhibit HCC. This article reviews the research advances in the mechanism of action of PP2A as a tumor factor in the regulation of HCC and target therapy.
