Role of adenosine monophosphate-activated protein kinase in acute pancreatitis
10.3969/j.issn.1001-5256.2019.10.052
- VernacularTitle:腺苷酸活化蛋白激酶在急性胰腺炎中的作用
- Author:
Lei HUANG
1
;
Xianlin ZHAO
;
Minghao WANG
Author Information
1. Department of Gastroenterology, Chengdu First People’s Hospital, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
pancreatitis;
adenylate kinase;
siganl transduction
- From:
Journal of Clinical Hepatology
2019;35(10):2365-2368
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate-activated protein kinase (AMPK) is a critical enzyme for energy and metabolic regulation and can effectively maintain the homeostasis of energy and metabolism in cells and the body, and thus it plays an important role in both health and diseases. Current studies have shown that AMPK can regulate inflammatory response in the body through various cytokines and signaling pathways such as nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) and has become a potential therapeutic target for a variety of inflammatory diseases. In acute pancreatitis, abnormal activation of trypsin can cause the injury and necrosis of tissue cells, release various inflammatory factors including NF-κB, TNF-α, and IL-6, and induce systemic inflammatory response, leading to organ injury or acute inflammatory disease. Recent studies indicate that the activation of AMPK can alleviate the inflammatory damage of acute pancreatitis. Therefore, AMPK and its signaling pathway may become potential therapeutic targets for acute pancreatitis.
