Research advances in the mechanism of action of intestinal microecology in intrahepatic cholestasis
10.3969/j.issn.1001-5256.2019.10.050
- VernacularTitle:肠道微生态在肝内胆汁淤积中的作用机制
- Author:
Qian HUANG
1
;
Haibo ZHANG
;
Jingtao LI
Author Information
1. Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712406, China
- Publication Type:Research Article
- Keywords:
cholestasis, intrahepatic;
gastrointestinal microbiome;
therapeutics
- From:
Journal of Clinical Hepatology
2019;35(10):2355-2359
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholestasis (IHC) is a dysfunction of bile production, secretion, and excretion caused by various factors including genetics, immunity, inflammation, stones, and tumors, and therefore, the bile is not normally discharged into the duodenum and reversely flows into blood, which causes a series of clinical diseases with organic damage, metabolic disorders, and dysfunction. In recent years, with the deepening of clinical and basic research, intestinal microecology is found to play an important role in the development and progression of liver diseases. This article reviews the mechanism of action of intestinal microecology and inflammatory factors in intrahepatic cholestasis and explores the research advances in the role of probiotics in regulating intestinal flora stability and improving intestinal microenvironment, so as to provide a basis for clinical treatment, scientific research, and drug research and development.
