Research advances in the role and mechanism of peroxisome proliferator-activated receptor alpha in liver diseases
10.3969/j.issn.1001-5256.2019.10.049
- VernacularTitle:过氧化物酶体增殖激活受体α在肝脏疾病中的作用及机制
- Author:
Dan ZHANG
1
;
Lanqing MA
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Research Article
- Keywords:
PPAR alpha;
liver diseases;
fatty liver
- From:
Journal of Clinical Hepatology
2019;35(10):2351-2354
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily and plays a central regulatory role in lipid metabolism. Recent studies have found that PPARα agonists play a key role in the prevention and treatment of nonalcoholic fatty liver disease, which has also been reported in other liver diseases. This article reviews the role and mechanism of PPARα in nonalcoholic fatty liver disease, alcoholic liver disease, viral hepatitis, cholestatic liver disease, drug-induced liver injury, and hepatocellular carcinoma, so as to provide a reference for the research on the new application of conventional drugs associated with PPARα.
