Persistence of rabies antibody 3 years after postexposure prophylaxis with 2-1-1 regimen of Vero-cell rabies vaccine for human use and antibody response to two booster doses
10.16462/j.cnki.zhjbkz.2019.05.023
- Author:
Zhu-hang HUANG
1
;
Jia-li SU
;
Hui-zhen ZHENG
;
Yi-bin ZHANG
;
Yan TANG
;
Yan-hui XIA
;
Yi-jian CHEN
;
Lei ZHANG
;
Ren-feng FAN
;
Ji-kai ZHANG
Author Information
1. Guangdong Provincial Institute of Biological Products and Materia Medica, Department of Biological Products Surveillance and Evaluation, Guangzhou 510440, China
- Publication Type:Research Article
- Keywords:
Rabies;
2-1-1 regimen;
Persistence
- From:
Chinese Journal of Disease Control & Prevention
2019;23(5):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the antibody persistence following rabies postexposure prophylaxis (PEP) with 2-1-1 regimen and antibody response to two booster doses. Methods A total of 314 healthy volunteers at year 1, year 2, year 3 who had received a complete rabies PEP using 2-1-1 regimen were recruited. Two booster doses of rabies vaccine were inoculated, and blood samples were obtained before and 14 days after two booster doses. Human rabies virus IgG antibody was evaluated by ELISA, and the antibody levels and antibody positive rates were analyzed. Results The antibody GMC of 303 people at year 1, year 2, year 3 after a complete immunization was 1.33 IU/mL, 1.04 IU/mL and 0.72 IU/mL, with an antibody positive rate of 77.78%, 66.67% and 55.56%, respectively. Among 282 people who received 2 doses for booster immunization, the antibody GMC at day 14 of 1 year, 2 year and 3 year immunization group was 16.83 IU/mL, 19.37 IU/mL and 21.05 IU/mL respectively, which was higher than that before booster immunization (t=16.54, P<0.001; t=13.85, P<0.001; t=16.02, P<0.001). The antibody positive rate was 100.00%, 99.00% and 100.00%, respectively. Conclusions The immune persistence of rabies antibody after PEP with antirabies vaccine using the 2-1-1 regimen is good so as to the immune response after 2 doses of booster immunization in 3 years is effective.
