Associations between normal serum levels of uric acid and knee symptoms, joint structures in patients with knee osteoarthritis
10.16462/j.cnki.zhjbkz.2019.05.022
- Author:
Fu-qin BIAN
1
;
Jian-hua XU
;
Kang WANG
;
Guang-feng RUAN
;
Jia-le REN
;
Bing-ru CHANG
;
Chang-hai DING
Author Information
1. Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China
- Publication Type:Research Article
- Keywords:
Osteoarthritis;
Uric acid;
Magnetic resonance imaging
- From:
Chinese Journal of Disease Control & Prevention
2019;23(5):602-606,612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations between normal serum uric acid (UA) levels and knee symptoms and structural changes in patients with knee osteoarthritis (OA).Methods A total of 205 patients with knee OA were enrolled. According to the inclusion and exclusion criteria, 122 patients with OA were included in the study. The general condition of patients were investingated. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score was used to assess severity of the knee joint symptoms. The Kellgren-Lawrence (K-L) grading system was used to assess radiological severity of the knee joint. Osirix software was used to assess changes of knee structure in magnetic resonance imaging (MRI). Peroxidase method was used to measure the serum levels of uric acid. Patients with normal range of uric acid were included in the study.Results The patients with lower levels of UA (split at the median level, 263 μmol/L) had a higher proportion of women, lower height, weight and lower proportions of K-L grade≥2. After adjustment for sex, age and body mass index, serum UA was negatively associated with total WOMAC scores (β=-16.15, P=0.018), WOMAC pain (β=-3.15, P=0.037), and WOMAC stiffness (β=-1.65, P=0.025). However, there were no significant associations between serum UA levels and knee joint structure changes.Conclusions In OA patients with normal serum UA, serum UA is negatively associated with the severity of joint symptoms, suggesting that UA within normal range may play a protective role in OA symptoms.
