Role of hepatocyte mitophagy in the pathogenesis of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2019.12.036
- VernacularTitle:肝细胞线粒体自噬在非酒精性脂肪性肝病发病机制中的作用
- Author:
Zhenhua ZHOU
1
;
Lingtai WANG
;
Yueqiu GAO
Author Information
1. Department of Hepatopathy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
adiponectin;
mitochondria;
autophagy
- From:
Journal of Clinical Hepatology
2019;35(12):2809-2811
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease has become the most important chronic liver disease in China and the leading cause of abnormal liver biochemical parameters in physical examination. Mitophagy can degrade the mitochondria with impaired function and misfolded protein in the liver to regulate cell death and help to maintain stable lipid metabolism in the liver. The binding of adiponectin secreted by adipose tissue to adiponectin receptor 2 can increase the secretion of autophagy agonists in Kupffer cells, induce hepatocyte mitophagy, promote lipid metabolism, and thus reduce liver inflammation, which provides new thoughts for the research and development of drugs with a marked clinical effect and a clear mechanism of action in the treatment of nonalcoholic fatty liver disease.
