Role of monocyte chemoattractant protein 1 and its receptor in the progression of liver fibrosis
10.3969/j.issn.1001-5256.2019.12.032
- VernacularTitle:单核细胞趋化蛋白-1及其受体在肝纤维化进程中的作用
- Author:
Yuecheng GUO
1
;
Lungen LU
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai 200080, China
- Publication Type:Research Article
- Keywords:
monocyte chemoattractant protein;
receptors, CCR2;
liver cirrhosis;
macrophages
- From:
Journal of Clinical Hepatology
2019;35(12):2793-2795
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a common reversible pathological change in chronic liver injury and may progress to liver cirrhosis, liver failure, and portal hypertension. In recent years, several studies have shown a significant change in chemokine profiles in patients with liver fibrosis, which is closely associated with the progression of liver fibrosis. Monocyte chemoattractant protein 1 (MCP-1) belongs to the family of CC chemokines and can induce the activation, recruitment, and migration of inflammatory cells during liver fibrosis. MCP-1 may be involved in the activation of hepatic stellate cells, the development of insulin resistance, and the progression to hepatocellular carcinoma. This article mainly reviews the potential role of MCP-1 and CC chemokine receptor in the progression of liver fibrosis and related therapies.
